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KMID : 0371320070730040315
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Journal of the Korean Surgical Society
2007 Volume.73 No. 4 p.315 ~ p.320
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Angiogenic and Lymphangiogenic Microvessel Density in Terms of the Expression of CD31 and D2-40 in Colon Cancer
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Youn Sang-In
Kim Beom-Gyu
Cha Sung-Jae
Park Sung-Jun
Chang In-Taek
Park Sung-Il
Lee Tae-Jin
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Abstract
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Purpose: Angiogenesis and lymphangiogenesis play important roles in the growth, progression and metastasis of colon cancer. We performed this study in order to investigate the significance of the CD31 and D2-40 expressions as prognostic factors in colon cancer.
Methods: The angiogenic and lymphagiogenic microvessel density was assessed by immunohistochemical staining of CD31 and D2-40 on samples that were resected from 66 patients with colorectal cancer.
Results: Strong correlation was observed between the CD31 microvessel density and being positive for having tumor emboli and lymph node metastasis (P=0.001, P=0.003). The D2-40 lymphatic vessel density was correlated with being positive for having tumor emboli (P=0.0001), the depth of invasion (P=0.0001), lymph node metastasis (P= 0.0001) and the cancer stage (P=0.0001). The D2-40 lymphatic vessel density was also correlated with the CD31 count (P=0.003).
Conclusion: These results suggested that the CD31 and D2-40 expressions are useful predictors of lymph node metastasis and they are prognostic factors for colon cancer
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KEYWORD
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Colon cancer, CD31, D2-40, Angiogenesis, Lymphangiogenesis
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